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    Home»Health»How can Merck pill prevent grave Covid infections- US health panel says
    Health

    How can Merck pill prevent grave Covid infections- US health panel says

    Victor KeitanyBy Victor KeitanyNovember 28, 2021Updated:November 28, 2021No Comments3 Mins Read
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    An anti-Covid pill developed by Merck has proved effective in treating the disease, the US Food and Drug Administration said Friday in a much-awaited preliminary report.

    But the report, from an FDA advisory panel, cautioned that pregnant women should not use the drug, known as molnupiravir, saying the potential benefits do not outweigh the risks for those patients.

    The report is meant to provide guidance to an FDA experts panel convening Tuesday to consider whether to authorize emergency use of molnupiravir.

    Approval, analysts say, would represent a major step forward in the battle against the global pandemic, handing healthcare professionals a powerful new tool to help those infected.

    Merck released the full results of the drug’s clinical trial Friday, which found the pill would reduce by 30 percent — much lower than its initial figure — the rate of hospitalizations and deaths in high-risk Covid patients who took it soon after infection.

    Pregnant women

    The preliminary FDA report confirmed the drug’s effectiveness in patients with mild to moderate Covid or at risk of hospitalization.

    In adding a caution against the drug’s use by pregnant women, the report noted that no pregnant women were included in the clinical trials.

    But it said tests involving pregnant rats and rabbits found higher rates of developing underweight and malformed fetuses after taking the drug.

    It cited “both known and possibly unknown risks in pregnant or lactating individuals and pediatric patients.”

    Merck, in its authorization request, said its data stemmed from trials conducted in partnership with Ridgeback Biotherapeutics in people with mild to moderate cases of Covid-19 and with at least one additional risk factor.

    They were given the drug within five days of symptoms first appearing.

    Merck initially said the drug, in a clinical trial, had been found to halve the rate of hospitalizations and deaths, before decreasing the rate in Friday’s full results.

    Those interim results were produced on the basis of studying slightly more than 700 patients, half of whom received the pill and half of whom got a placebo.

    The finding — a 48 percent reduction rate — was statistically significant, and considered persuasive enough that an independent data review committee decided, in consultation with the FDA, to halt the drug trial ahead of schedule.

    1,400 patients

    The full results were based on analysis of more than 1,400 patients, resulting in the more modest reduction rate of hospitalization and death.

    Both the interim and complete results “support the efficacy and overall favorable benefit-risk assessment of molnupiravir” for treating mild to moderate Covid-19 in high risk adults, Merck said in a press release.

    The full results found the hospitalization rate among patients who received the drug was 6.8 percent, compared to 9.7 percent for those given a placebo.

    Just one of those treated died, while the second group saw nine deaths.

    Antiviral drugs like molnupiravir work by reducing the ability of a virus to reproduce itself.

    The drugs may be useful not only in keeping infected people from developing more serious symptoms, but in preventing people who have had prolonged exposure to the virus from falling ill.

    The pill can be dispensed by a pharmacy and taken at home, whereas the three authorized monoclonal antibodies authorized for treating mild to moderate Covid-19 in at-risk individuals must be administered intravenously or through injection, the FDA report noted.

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    Victor Keitany

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